Glycerin
No Known RisksGlycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation

Safety score
Pregnancy-focused assessment
No higher-risk ingredients were identified in MamaSkin's current assessment. Check the latest package before deciding.
Formula and assessment check
Ingredient safety review updated 23 November 2025. Product formulas can change, so compare the ingredients shown here with the packaging you have.
Report a formula mismatchSee how the listed formula falls across MamaSkin's pregnancy-focused risk bands.
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No known risks
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Low risk
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Medium risk
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High risk
Ingredients with a higher risk flag appear first, followed by the rest of the formula.
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
An amino-acid-derived surfactant or conditioning ingredient. Cosmetic safety reviewers concluded that amino acid alkyl amides are safe in current cosmetic practices when formulated to be non-irritating. Manufacturing and formulation should control nitrosamine formation where relevant.
Sources: CIR: Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-amino-acid-alkyl-amides-used-cosmetics-0
An amino-acid-derived surfactant or conditioning ingredient. Cosmetic safety reviewers concluded that amino acid alkyl amides are safe in current cosmetic practices when formulated to be non-irritating. Manufacturing and formulation should control nitrosamine formation where relevant.
Sources: CIR: Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-amino-acid-alkyl-amides-used-cosmetics-0
1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.
Sources: CIR; EU/UK Cosmetics Regulation
A modified starch used mainly to thicken and stabilize cosmetic formulas. Cosmetic safety reviewers concluded that starch phosphates, including hydroxypropyl starch phosphate, are safe in current cosmetic use. No pregnancy- or breastfeeding-specific concern is identified for normal topical exposure.
Sources: CIR: Safety Assessment of Starch Phosphates https://cir-safety.org/sites/default/files/FR_StarchPhosphates_092022.pdf
Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
An amphoteric surfactant used for cleansing and foam support. Cosmetic safety reviewers concluded that alkyl betaines, including lauryl betaine, are safe in current practices when formulated to be non-irritating. Local irritation is possible in concentrated or harsh formulas.
Sources: CIR: Final Safety Assessment of Alkyl Betaines, March 2014; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf
Hydroxyacetophenone is used as an antioxidant and preservative-support ingredient; it is generally considered low concern in topical cosmetic use with no known pregnancy or breastfeeding risks at typical concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
vigna radiata seed extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.
Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng
Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
Sodium chloride is used to adjust viscosity and texture in formulations; topical cosmetic use is considered low concern with no known pregnancy or breastfeeding risks.
Sources: CIR; EU/UK Cosmetics Regulation
Volatile solvent used in some toners, sprays, and lightweight formulas. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed; the main practical issue is dryness, stinging, or barrier disruption in some users.
Sources: CIR: Safety Assessment of SD Alcohol 40, Benzyl Alcohol, and Denatured Alcohol in Cosmetic Products; EU CosIng / cosmetics regulatory inventory
Betaine is a humectant/osmolyte used to support hydration and reduce irritation potential in formulas; it is considered low concern with no known pregnancy or breastfeeding risks in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
A cationic conditioning and film-forming polymer. Cosmetic Ingredient Review assessments concluded that the named polyquaterniums are safe in current cosmetic practices, in some cases with the condition that formulations be non-irritating. Their large polymeric structures limit expected passage through intact skin. No pregnancy- or reproductive-toxicity signal was identified for normal topical cosmetic exposure.
Sources: CIR: December 2025 Quick Reference Table, conclusions for Polyquaternium-6, -22, -28, -32, -39, -47, -53, -61 and -73 https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf; CIR: Safety Assessment of Polyquaternium-22 and Polyquaternium-39 https://www.cir-safety.org/supplementaldoc/safety-assessment-polyquaternium-22-and-polyquaternium-39-used-cosmetics; CIR: Safety Assessment of Polyquaternium-6 https://www.cir-safety.org/supplementaldoc/safety-assessment-polyquaternium-6-used-cosmetics
Neem leaf extract is used topically for skin conditioning and antimicrobial support. Reproductive concerns reported for concentrated neem seed preparations, intrauterine exposure, or high oral doses do not establish a hazard from normal topical cosmetic exposure to a leaf extract.
Sources: PubMed: oral purified neem seed extracts in primates https://pubmed.ncbi.nlm.nih.gov/8773426/; PubMed: intrauterine neem oil in primates https://pubmed.ncbi.nlm.nih.gov/8143455/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic leaf-extract use was identified.
Neem flower extract is used as a botanical skin-conditioning ingredient. A high-dose oral rat study altered the oestrous cycle and ovulation but did not show anti-implantation, abortifacient, or teratogenic effects. That oral dose does not establish a hazard from normal topical cosmetic exposure.
Sources: PubMed: high-dose oral neem flower extract reproductive study in rats https://pubmed.ncbi.nlm.nih.gov/19357745/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic use was identified.
Starch-derived polysaccharide used as a binder, film former and texture support ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.
Sources: CIR cosmetic ingredient safety references for polysaccharides/starch-derived ingredients; EU CosIng / cosmetics regulatory inventory
A cosmetic extract from an edible fruit, seed, grain, root or mushroom used for conditioning or antioxidant support. Normal topical cosmetic exposure is much lower than ordinary dietary exposure to the source material, and no pregnancy-specific hazard signal was identified. Exact extract composition varies, so source quality and individual food or plant allergy remain relevant.
Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; FDA food ingredient and GRAS inventories where applicable.
An ivy-gourd fruit extract used for skin conditioning and antioxidant support. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.
Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.
Allantoin is a soothing skin protectant commonly used to help reduce irritation and support comfort, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Phellodendron bark extract can contain biologically active alkaloids, with composition depending on extraction and source. Oral berberine cautions are not evidence of equivalent exposure from a topical cosmetic extract. No pregnancy-specific hazard was identified for normal topical cosmetic use.
Sources: PubMed: constituents and biological activity of Phellodendron amurense bark https://pubmed.ncbi.nlm.nih.gov/28425165/; European Commission CosIng ingredient inventory. No human pregnancy study of topical cosmetic use was identified.
An aloe flower extract used for skin conditioning. Cosmetic safety reviewers concluded that supported Aloe barbadensis-derived ingredients are safe in current practices, with anthraquinone impurities controlled to no more than 50 ppm. No pregnancy-specific concern was identified for normal topical cosmetic exposure.
Sources: CIR: December 2025 Quick Reference Table, Aloe Barbadensis Flower Extract conclusion https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf
A fruit, seed or food-plant extract used for skin conditioning and antioxidant support. No pregnancy-specific signal was identified for the low topical exposure expected from a finished cosmetic. Direct pregnancy studies are generally unavailable, and botanical allergy remains possible.
Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant fruit-derived ingredient assessments; peer-reviewed cosmetic and phytochemical literature for the named plants.
Preservative widely used in foods and cosmetics. Considered safe at regulated concentrations with low systemic exposure from topical use.
Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework
Holy basil leaf extract is used for antioxidant and skin-conditioning purposes. Available warnings and pharmacology largely concern oral herbal use. No pregnancy-specific systemic hazard was identified for normal topical exposure to a compliant cosmetic, although botanical sensitivity remains possible.
Sources: PubMed: oral toxicological evaluation of Ocimum sanctum leaf extract https://pubmed.ncbi.nlm.nih.gov/24616736/; European Commission CosIng ingredient inventory. No human pregnancy study of topical cosmetic use was identified.
A red-algae-derived extract used for skin conditioning, hydration or formula texture. Cosmetic safety reviewers concluded that the assessed red algae ingredients, including this extract, are safe in current practices of use and concentration. Cosmetic manufacturers should control naturally occurring contaminants such as heavy metals and arsenic.
Sources: CIR: Safety Assessment of Red Algae-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=cef5b6e9-8c74-ec11-8943-0022482f06a6
Turmeric root extract is used for antioxidant and skin-conditioning effects. Pregnancy cautions relate mainly to concentrated oral supplements; normal topical cosmetic exposure is substantially smaller. The principal topical concern is irritation or allergy in sensitive users.
Sources: NIH NCCIH: Turmeric safety, including separate oral-supplement and topical cautions https://www.nccih.nih.gov/health/turmeric; European Commission CosIng ingredient inventory.
A Roman chamomile flower extract or oil used for skin conditioning and fragrance. Cosmetic safety reviewers concluded that Anthemis nobilis-derived ingredients are safe in current practices when formulated to be non-sensitising. People allergic to plants in the daisy family may be more likely to react.
Sources: CIR: Safety Assessment of Anthemis nobilis-Derived Ingredients as Used in Cosmetics https://cir-safety.org/sites/default/files/anthem122013final.pdf
Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.
Sources: Cosmetic Ingredient Review (US)
Botanical skin-conditioning ingredient used in soothing and barrier-support formulas. Reviewed cosmetic safety sources support current cosmetic use when formulated to be non-sensitising, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: CIR: Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
A fruit, seed or food-plant extract used for skin conditioning and antioxidant support. No pregnancy-specific signal was identified for the low topical exposure expected from a finished cosmetic. Direct pregnancy studies are generally unavailable, and botanical allergy remains possible.
Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant fruit-derived ingredient assessments; peer-reviewed cosmetic and phytochemical literature for the named plants.
Skin-identical barrier lipid used to support the stratum corneum and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Formulations can change without notice. For the most accurate result, compare this list with your packaging and scan the exact ingredient label in MamaSkin when you repurchase.
The risk band is the primary conclusion. The score adds detail within that band and should not be used to compare products as if a one-point difference were clinically meaningful.
MamaSkin provides pregnancy-focused information, not medical advice. Your midwife, GP, pharmacist or dermatologist should take priority when your circumstances differ from typical cosmetic use.