Medicube PDRN Pink Collagen Volume Multi Balm

DNA-derived cosmetic ingredient/label term used in topical PDRN or polynucleotide-style skincare. Topical cosmetic use is not currently treated as a known pregnancy-restricted concern, but pregnancy-specific clinical data remain limited. MamaSkin scores this conservatively as low risk to reflect the evidence gap. This assessment applies to topical cosmetic products only and does not apply to injectable or in-clinic PDRN/polynucleotide treatments. Always review co-ingredients such as retinoids, hydroquinone, high-strength acids or other pregnancy-restricted actives separately.

Recombinant human oligopeptide cosmetic ingredient used in topical growth-factor-style formulas, commonly associated with EGF-style skin-conditioning claims. Normal topical cosmetic use is not currently treated as a known pregnancy-restricted concern, and these larger signaling peptides are expected to have limited intact-skin penetration. Pregnancy- and breastfeeding-specific cosmetic data are limited, so MamaSkin scores this conservatively as low risk rather than no known risks. This assessment applies to topical cosmetic products only, not injectable growth-factor treatments, microneedling serums, wound use, or oral supplements.

Recombinant human oligopeptide cosmetic ingredient used in topical growth-factor-style skin-conditioning formulas. Normal topical cosmetic use is not currently treated as a known pregnancy-restricted concern, but pregnancy- and breastfeeding-specific cosmetic data are limited. Because this ingredient is biologically framed as a signaling peptide rather than a simple cosmetic conditioning peptide, MamaSkin scores it conservatively as low risk. This assessment applies to topical cosmetic products only, not injectable growth-factor treatments, microneedling serums, wound use, or oral supplements.

Recombinant human polypeptide cosmetic ingredient used in topical growth-factor-style skin-conditioning formulas. Normal topical cosmetic use is not currently treated as a known pregnancy-restricted concern, and large peptide/protein ingredients are expected to have limited intact-skin penetration. Pregnancy- and breastfeeding-specific cosmetic data are limited, so MamaSkin scores this conservatively as low risk rather than no known risks. This assessment applies to topical cosmetic products only, not injectable growth-factor treatments, microneedling serums, wound use, or oral supplements.

SH-Polypeptide-11 is a recombinant human polypeptide used in growth-factor-style skin or hair formulas. Pregnancy and breastfeeding studies of topical cosmetic use are lacking, while intact-skin systemic absorption of a protein-sized ingredient is expected to be limited. Low Risk keeps it consistent with MamaSkin's SH-Polypeptide-1 and SH-Polypeptide-9 policy.

sh-Polypeptide-3 is a recombinant human keratinocyte-growth-factor-style protein used in topical conditioning formulas. Intact-skin absorption is expected to be limited, but pregnancy and breastfeeding studies are lacking. MamaSkin scores it conservatively as Low Risk, consistent with other recombinant sh-polypeptides.

Recombinant human polypeptide cosmetic ingredient used in topical growth-factor-style skin-conditioning formulas. Normal topical cosmetic use is not currently treated as a known pregnancy-restricted concern, but pregnancy- and breastfeeding-specific cosmetic data are limited. Because this is a biologically framed signaling protein rather than a simple cosmetic conditioning peptide, MamaSkin scores it conservatively as low risk. This assessment applies to topical cosmetic products only, not injectable growth-factor treatments, microneedling serums, wound use, or oral supplements.

Lightweight emollient ester used to improve slip and skin feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Inert wax/structuring ingredient used to add body, stability and texture to cosmetics. Normal topical use is expected to have low systemic exposure, with no pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

An ester of diglycerin and isostearic acid used as an emollient and emulsifier. Cosmetic safety reviewers assessed polyglyceryl fatty acid esters, including this ingredient, as safe in current cosmetic use when formulated to be non-irritating. No pregnancy-specific concern is identified for normal topical exposure.

Emollient ester commonly used in lip, makeup and skin-care formulas for cushion and gloss. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Highly refined mineral wax used to thicken and stabilise formulas. Cosmetic-grade microcrystalline wax has minimal skin absorption and no known pregnancy-specific concerns in topical use as intended. Concerns raised online typically relate to unrefined mineral oil impurities or dietary exposure, not cosmetic-grade topical use.

Inert synthetic emollient used as a glossing and occlusive agent. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Fatty alcohol emollient used to improve spreadability and reduce drag. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

This wax is used as an emollient and structuring ingredient. Cosmetic Ingredient Review assessments support current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified; uncommon contact allergy can occur, particularly with natural wax components.

A terpene alcohol used for skin conditioning and soothing. Cosmetic safety reviewers reaffirmed bisabolol as safe at current cosmetic concentrations, and reproductive and developmental testing did not identify adverse effects. Bisabolol can increase skin penetration, so formulators should consider the safety of other ingredients in the same product.

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

polyglyceryl-2 oleate is a cosmetic emollient, ester or lipid-derived formulation aid. Relevant family evidence supports normal cosmetic use with irritation, sensitisation and purity qualifications retained where applicable. No pregnancy-specific concern was identified for ordinary topical exposure.

This plant-derived fatty oil or butter is used as an emollient and skin-conditioning ingredient. The Cosmetic Ingredient Review concluded that assessed plant-derived fatty acid oils are safe as used in cosmetics; individual plant allergy and ingredient purity remain practical considerations.

Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Helianthus annuus (sunflower) seed oil is a common emollient rich in fatty acids and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Geranium oil is used in cosmetics mainly as a fragrance botanical. Direct pregnancy-specific data are sparse, but no clear pregnancy-specific dermal harm signal has been established for routine diluted cosmetic use. This assessment does not cover concentrated essential-oil use, ingestion, or non-cosmetic therapeutic exposure. The more relevant practical issues are fragrance sensitisation and local irritation, so within this methodology it remains in no known risks.

A botanical extract or plant water used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Ylang-ylang oil is used in cosmetics mainly as a fragrance ingredient. There is no established pregnancy-specific concern from typical topical cosmetic exposure. The main issue is fragrance sensitisation or allergic contact dermatitis in susceptible users, rather than reproductive toxicity.

Bergamot essential oil used mainly for fragrance. No pregnancy-specific hazard is established for normal topical cosmetic exposure. Expressed bergamot oil can be phototoxic unless furocoumarins are controlled, so sun-exposed use should follow the finished product directions and applicable fragrance standards.

Rose flower oil is a concentrated fragrance botanical. At normal cosmetic topical use levels, there is no established pregnancy-specific concern. The more relevant issues are irritation and sensitisation from fragrance constituents, which this methodology does not treat as a pregnancy-specific risk.

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Methylxanthine used in cosmetics (e.g., de-puffing/firming and antioxidant support). No pregnancy-specific contraindications are identified for topical cosmetic use.

A structural protein or hydrolysed peptide used for skin or hair conditioning. Cosmetic safety reviewers concluded that the assessed skin and connective-tissue-derived proteins are safe in current practices, subject to appropriate animal-source and impurity controls. Protein sensitivity remains possible.

A plant-derived oil or hydrogenated wax used mainly as an emollient and skin-conditioning ingredient. Cosmetic safety reviewers concluded that these named sea buckthorn, tea seed, jojoba and grape seed ingredients are safe in current practices of use and concentration. Plant allergy remains possible.

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Plant-derived emollient oil used to soften skin and support formula texture. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

A polyglycerin fatty-acid ester used as an emulsifier, dispersant or emollient. Cosmetic safety reviewers concluded that the assessed family of 274 polyglyceryl fatty acid esters is safe in current practices when formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

adenosine triphosphate is an amino-acid, peptide, protein or related conditioning ingredient. Relevant cosmetic-family assessments support topical use, and expected systemic exposure is low. No pregnancy-specific concern was identified for normal intact-skin use; residual allergenic proteins and manufacturing quality remain relevant.

nicotinamide adenine dinucleotide is a vitamin, vitamin derivative or endogenous cofactor used as a cosmetic conditioning or antioxidant ingredient. No pregnancy-specific concern was identified for normal topical cosmetic exposure. This classification does not extend to medicinal vitamin analogues, high-dose treatment or oral supplementation.

Emulsifier and skin-conditioning ingredient composed of phospholipids. Not associated with pregnancy-specific concerns.

An inorganic phosphate salt used mainly to buffer or adjust the pH of a formula. Cosmetic safety reviewers concluded that phosphoric acid and its simple salts, including sodium phosphate, are safe in current cosmetic use when products are formulated to avoid irritation. No pregnancy-specific concern is identified for normal topical exposure.

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

A structural protein or hydrolysed peptide used for skin or hair conditioning. Cosmetic safety reviewers concluded that the assessed skin and connective-tissue-derived proteins are safe in current practices, subject to appropriate animal-source and impurity controls. Protein sensitivity remains possible.

Synthetic peptide used as a skin-conditioning ingredient. Reviewed cosmetic safety sources do not indicate a known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use. The available cosmetic safety assessment concluded this ingredient is safe in cosmetics at concentrations up to 0.005%; safety above that concentration was not established in the reviewed report.

Copper-binding carrier peptide also known as GHK-Cu, used topically in cosmetic skin-renewal, anti-aging, barrier-support and hair/scalp products. Reviewed literature describes topical cosmetic use and does not identify a pregnancy- or breastfeeding-specific risk signal for normal topical use. This assessment does not apply to injectable copper peptides or oral peptide/copper supplementation.

Synthetic palmitoylated signal peptide used in topical anti-aging cosmetics. It is one of the better-studied cosmetic peptides, with reviewed topical literature describing controlled cosmetic studies and no pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Synthetic acetylated peptide used in topical eye, anti-aging and skin-conditioning formulas. Reviewed topical peptide literature lists acetyl tetrapeptide-5 among cosmetic peptides, with no pregnancy- or breastfeeding-specific concern identified for normal topical cosmetic use.

Synthetic signal peptide used in topical cosmetic anti-aging and skin-conditioning formulas. Reviewed topical peptide literature describes palmitoyl tetrapeptide-7 as a cosmetic peptide with anti-inflammatory and extracellular-matrix support activity in topical formulations. No pregnancy- or breastfeeding-specific risk signal was identified for normal topical cosmetic use.

Synthetic peptide used as a skin-conditioning ingredient. Reviewed cosmetic safety sources indicate no known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use. Available cosmetic safety assessments conclude this ingredient is safe in the present practices of use and concentration described for cosmetics.