MediCube Triple Collagen Cream

Aesculus Hippocastanum Extract is an unqualified horse-chestnut extract whose INCI name does not state the plant part or preparation. EMA says pregnancy and lactation safety of medicinal horse-chestnut seed preparations has not been established and does not recommend those medicinal preparations when data are absent. Ordinary topical cosmetic exposure is substantially lower than medicinal use, and no established reproductive hazard supports a higher band, so MamaSkin uses precautionary Low Risk rather than Medium or High Risk.

Dimethicone is a silicone polymer used as a skin protectant and slip/conditioning agent. It is considered inert with minimal dermal absorption; the main practical issues are cosmetic (feel) and occasional irritation in very sensitive users. It is not a pregnancy-specific concern in topical cosmetic use.

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Dipropylene glycol is used as a solvent and carrier in cosmetics; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Fatty alcohol used as an emollient and thickener. Not the same as drying alcohols and not associated with pregnancy-specific concerns.

Silicone emollient and solvent used to improve slip and spreadability. No known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use based on reviewed cosmetic safety sources. Spray or aerosol formats may warrant extra caution because inhalation/local lung exposure concerns have been raised for those uses.

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Light emollient triglyceride used to improve spreadability and reduce drag. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Synthetic hydrocarbon emollient used to improve slip, cushion and moisture feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

A large hydrogenated hydrocarbon polymer used as an emollient and texture agent. Cosmetic safety reviewers assessed hydrogenated poly(C6-14 olefin) with cosmetic polyenes and concluded that the group is safe in current practices of use and concentration. Dermal absorption is expected to be limited by molecular size.

Self-emulsifying form of glyceryl stearate used to stabilize creams and lotions. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific concern identified.

A Japanese-yam root extract used as a moisturising and skin-conditioning botanical. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

A red or brown algae-derived ingredient used for skin conditioning, hydration or texture. Cosmetic safety reviewers concluded that Laminaria japonica extract and the assessed Chondrus crispus ingredients are safe in current practices of use and concentration. Seaweed allergy remains possible in a susceptible person.

A botanical extract, juice or water used primarily for skin conditioning, moisturising, soothing or antioxidant support. Direct pregnancy studies of the named cosmetic material were not identified. No reproductive or developmental hazard was identified for normal topical exposure to a compliant finished cosmetic; oral herbal or medicinal use is outside this classification.

An animal-derived protein, peptide or secretion filtrate used for hydration and skin conditioning. These large components are expected to have low systemic absorption through intact skin. No pregnancy-specific hazard signal was identified for normal topical cosmetic use. Cosmetic-grade materials should be processed to control microorganisms, infectious agents and source-derived impurities, and protein allergy remains possible.

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Argan oil is a plant-derived emollient oil used for skin and hair conditioning. Normal topical cosmetic use has no known pregnancy- or breastfeeding-specific concern; users with plant/nut sensitivities should follow personal tolerance.

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Emollient ester/emulsifier used to improve skin feel and stabilise emulsions. Reviewed cosmetic safety sources support topical cosmetic use; the relevant practical caveat is formulation irritation potential rather than a pregnancy-specific concern.

A long-chain fatty alcohol or fatty-alcohol blend used as an emollient, thickener or stabiliser. These are not volatile drying alcohols. CIR safety assessments support use of lauryl, oleyl and related fatty alcohols in current cosmetic practices, and no pregnancy-specific hazard signal was identified for normal topical exposure.

Emulsifier and emollient used to stabilise creams and lotions. Not associated with pregnancy-specific concerns at cosmetic exposure.

Emulsifier used to stabilize creams and lotions. Reviewed cosmetic safety sources support use of PEG stearates in cosmetics, with no pregnancy- or breastfeeding-specific concern identified for normal topical use.

This cellulose or modified-cellulose polymer is used as a thickener, film former or stabilizer. Cosmetic Ingredient Review data indicate that cellulose polymers do not appreciably penetrate skin and are safe in current cosmetic use, with at most minimal irritation reported.

Sugar-based emulsifier used to stabilise creams and lotions. Reviewed cosmetic safety sources support topical cosmetic use; the relevant practical caveat is formulation irritation potential rather than a pregnancy-specific concern.

Olive-derived sorbitan ester used as an emulsifier and skin-conditioning ingredient. Reviewed cosmetic safety references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

This sugar or sugar alcohol is used as a humectant and skin-conditioning ingredient. Cosmetic Ingredient Review assessments support these saccharides in current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified for normal topical exposure.

Large polymer thickener, stabilizer and texture ingredient used in gels, creams and sunscreens. Systemic exposure from topical cosmetic use is expected to be low, with no pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Lightweight emollient used to support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Fatty acid used as an emollient, cleansing-support and texture ingredient. It is not associated with pregnancy- or breastfeeding-specific concerns in normal topical cosmetic use.

Betaine is a humectant/osmolyte used to support hydration and reduce irritation potential in formulas; it is considered low concern with no known pregnancy or breastfeeding risks in topical cosmetic use.

Cellulose-derived thickener and binder used to stabilise texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

A starch derivative used for absorbency, texture and formula stability. Cosmetic safety reviewers concluded that the assessed starches and modified starches are safe in current practices.

Nonionic emulsifier and solubilizer used to help oil and water phases mix. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Inert synthetic emollient used as a glossing and occlusive agent. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Film-forming polysaccharide used for soothing and hydration support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Volatile solvent used in some toners, sprays, and lightweight formulas. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed; the main practical issue is dryness, stinging, or barrier disruption in some users.

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Emollient ester used for lightweight slip and a dry skin feel in makeup and skin care. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

An ester of polyglycerin and stearic acid used as an emulsifier and skin-conditioning ingredient. Cosmetic safety reviewers concluded that polyglyceryl fatty acid esters, including Polyglyceryl-10 Stearate, are safe in current cosmetic use when formulated to be non-irritating.

Emulsifier used to help oil and water phases remain mixed. Reviewed cosmetic safety sources support topical use in cosmetics; the main practical issue is irritation potential in some formulas rather than a pregnancy-specific concern.

This sugar or sugar alcohol is used as a humectant and skin-conditioning ingredient. Cosmetic Ingredient Review assessments support these saccharides in current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified for normal topical exposure.

Stearic acid is a fatty acid used to stabilise emulsions and improve texture; it is considered low concern in topical cosmetics with no known pregnancy or breastfeeding risks at typical concentrations.

Butyrospermum parkii (shea) butter is an emollient/occlusive that supports the skin barrier; topical use is considered low concern with no known pregnancy or breastfeeding risks.

A polyglycerin fatty-acid ester used as an emulsifier, dispersant or emollient. Cosmetic safety reviewers concluded that the assessed family of 274 polyglyceryl fatty acid esters is safe in current practices when formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Short plant-derived carbohydrate chains used for skin conditioning and formula support. Cosmetic safety reviewers assessed fructooligosaccharides with plant polysaccharide gums and concluded that the group is safe in current practices. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

A sugar, starch, inulin or cellulose derivative used for emulsification, film formation, absorbency or formula texture. These carbohydrate-based materials are not expected to produce meaningful systemic exposure through intact skin, and related cosmetic safety assessments do not identify a reproductive or developmental hazard for normal use. Fine dry powder should not be deliberately inhaled.

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.

An amino-acid-derived surfactant or conditioning ingredient. Cosmetic safety reviewers concluded that amino acid alkyl amides are safe in current cosmetic practices when formulated to be non-irritating. Manufacturing and formulation should control nitrosamine formation where relevant.

A structural protein or hydrolysed peptide used for skin or hair conditioning. Cosmetic safety reviewers concluded that the assessed skin and connective-tissue-derived proteins are safe in current practices, subject to appropriate animal-source and impurity controls. Protein sensitivity remains possible.

A structural protein or hydrolysed peptide used for skin or hair conditioning. Cosmetic safety reviewers concluded that the assessed skin and connective-tissue-derived proteins are safe in current practices, subject to appropriate animal-source and impurity controls. Protein sensitivity remains possible.

High-water-binding humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

A filtered radish-root fermentation product used mainly for skin conditioning and formulation support. Cosmetic safety reviewers concluded that the reviewed radish-root-derived ingredients, including Leuconostoc/Radish Root Ferment Filtrate, are safe in current cosmetic use when formulated to be non-irritating. Testing at cosmetic-relevant concentrations did not identify irritation, sensitization, phototoxicity or ocular irritation concerns.

Preservative widely used in foods and cosmetics. Considered safe at regulated concentrations with low systemic exposure from topical use.

Linalool is a common fragrance component used at low levels in cosmetics; it is not a pregnancy-specific concern in topical use, but it is a recognised fragrance allergen and may trigger irritation or sensitisation in some people, especially if the product oxidises over time.

Limonene is a common fragrance component used at low levels in cosmetics; it is not a pregnancy-specific concern in topical use, but it is a recognised fragrance allergen and may trigger irritation or sensitisation in some people, especially if the product oxidises over time.