Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum by Estée Lauder
Estée Lauder

Advanced Night Repair Synchronized Multi-Recovery Complex Serum

Serums

58/100
Medium risk

Pregnancy-focused rating

This formula needs extra consideration during pregnancy. Review the flagged ingredients with your healthcare professional.

43 of 43 ingredients rated

Is it suitable during pregnancy?

MamaSkin rates the recorded formula for Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum as Medium risk (58/100). Discuss the flagged ingredients with a qualified healthcare professional before using this formula during pregnancy.

Why this rating?

The recorded formula includes 3 ingredient entries with risk flags: BHT (Medium risk), Triethanolamine (Low risk), Phenoxyethanol (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail.

43 of 43 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.

How we assess products

Ingredient breakdown

The recorded formula, with evidence behind each rating. Unmatched ingredients are marked Not assessed in grey.

Ingredient ratings and evidence

Higher-risk flags first. Open an ingredient for evidence.

BHT

Medium risk

BHT (butylated hydroxytoluene) is a lipophilic antioxidant used to protect oils from oxidation. Animal studies at high (primarily oral) doses show liver enzyme induction and related biochemical changes; endocrine-screening lines of evidence have also been evaluated in regulatory reviews. Pregnancy-specific human outcome data for topical cosmetic exposure are limited; the key signal is systemic toxicology at higher exposures and uncertainty for pregnancy-specific outcomes.

Sources: SCCS/1636/21: Butylated hydroxytoluene https://health.ec.europa.eu/publications/butylated-hydroxytoluene-bht_en

Triethanolamine

Low risk

Triethanolamine (TEA) is an alkanolamine used as a pH adjuster and surfactant in cosmetics. The main practical concerns are skin/eye irritation at higher concentrations and the potential formation of nitrosamines if formulated with nitrosating agents (a formulation/impurity-control issue). It is not a typical pregnancy-specific concern at cosmetic use levels; overall risk is primarily local irritation/sensitisation in susceptible users.

Sources: CIR: Triethanolamine ingredient safety information https://www.cir-safety.org/ingredient/triethanolamine

Phenoxyethanol

Low risk

Phenoxyethanol is a preservative permitted in EU cosmetics up to 1.0%. The SCCS concluded it is safe for cosmetic use at that level, including when considering higher cosmetic exposure scenarios in infants and young children. Main practical concern is irritation/stinging on very sensitive or compromised skin rather than a pregnancy- or breastfeeding-specific risk.

Sources: SCCS/1575/16: Phenoxyethanol opinion https://health.ec.europa.eu/publications/phenoxyethanol_en

Water

No known risks

Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.

Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en

Bifida Ferment Lysate

No known risks

A non-live bacterial fermentation lysate used for skin conditioning. It is not the same as applying live bacteria. Available cosmetic safety information and the nature of the processed material do not identify a pregnancy-specific concern for normal topical exposure.

Sources: CIR yeast and bacterial ferment strategy and safety assessments; European Commission CosIng ingredient inventory for Bifida Ferment Lysate.

Show all 43 ingredients

PEG-8

No known risks

A small polyethylene glycol used as a humectant and solvent. Cosmetic safety reviewers concluded that PEG-8 is safe at current cosmetic concentrations, but PEG ingredients should not be used on damaged skin and manufacturing impurities must be controlled. No pregnancy-specific concern was identified for compliant topical use.

Sources: CIR: Final Report on the Safety Assessment of Polyethylene Glycols https://cir-reports.cir-safety.org/view-attachment/?id=0ca16b53-8e74-ec11-8943-0022482f06a6

Propanediol

No known risks

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Bis-PEG-18 Methyl Ether Dimethyl Silane

No known risks

An ethoxylated silicone used as a humectant, emulsifier and skin-conditioning ingredient. Cosmetic safety assessments of PEG-modified silicones support current topical uses, with low expected absorption of the intact material and control of manufacturing impurities.

Sources: CIR: Safety Assessment of PEG/PPG-modified silicones, including methyl ether dimethicones; CIR December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Methyl Gluceth-20

No known risks

A glucose-derived humectant and conditioning ingredient. Cosmetic safety reviewers concluded that methyl gluceth-20 is safe as used in cosmetics; reviewed skin testing did not indicate sensitisation. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Final Report on the Safety Assessment of Methyl Gluceth-10 and Methyl Gluceth-20 https://cir-reports.cir-safety.org/view-attachment?id=fb9dc889-8e74-ec11-8943-0022482f06a6

Glycereth-26

No known risks

An ethoxylated glycerin humectant used to retain moisture and improve product texture. The Cosmetic Ingredient Review assessed glycerin ethoxylates including Glycereth-26 for current cosmetic use; available evidence does not identify a pregnancy- or breastfeeding-specific concern from normal topical exposure.

Sources: CIR: Safety Assessment of Glycerin Ethoxylates https://cir-safety.org/supplementaldoc/safety-assessment-glycerin-ethoxylates-used-cosmetics

PEG-75

No known risks

peg-75 is a cosmetic polymer or polymeric formulation aid. The reviewed material is distinct from any free reactive monomers; systemic dermal absorption is expected to be limited by molecular size when manufactured with appropriate impurity controls. No pregnancy-specific concern was identified for normal cosmetic use, although products should be formulated to avoid irritation.

Sources: CIR polymer safety assessments and Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf; European Commission CosIng ingredient inventory

Butylene Glycol

No known risks

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Adansonia Digitata Seed Extract

No known risks

adansonia digitata seed extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

Tripeptide-32

No known risks

The defined short skin-conditioning peptide has no identified pregnancy-specific risk at ordinary diluted topical exposure.

Sources: https://patentimages.storage.googleapis.com/57/f1/03/3241e6e95c6048/US20090220481A1.pdf, https://pubmed.ncbi.nlm.nih.gov/41953401/

Sodium Hyaluronate

No known risks

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Yeast Extract

No known risks

A yeast-derived ferment, filtrate or extract used for skin conditioning. Cosmetic safety reviewers concluded that cosmetic ingredients derived from the reviewed yeast species are safe in current practices; this record applies to the standardized cosmetic INCI material, not an unspecified live culture.

Sources: CIR: Yeast-derived ingredients final assessment, June 2024; Galactomyces Ferment Filtrate conclusion; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Lactobacillus Ferment

No known risks

Ferment-derived skin-conditioning ingredient used in microbiome-support and soothing formulas. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Lactobacillus Ferment Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Cola Acuminata Seed Extract

No known risks

Kola-seed extract contains caffeine, theobromine and catechins. Caffeine has systemic effects, and pregnancy advice about dietary intake does not establish a safe concentration for every cosmetic. No pregnancy-specific harm has been identified from ordinary dilute topical use of the native seed extract, where systemic exposure is expected to be lower than ingestion. Concentrated stimulant preparations and enhanced transdermal delivery are not covered.

Sources: https://kcia.or.kr/cid/search/ingd_view.php?no=3080, https://www.sciencedirect.com/science/article/pii/S025462990800224X, https://doi.org/10.2903/j.efsa.2015.4102

Anthemis Nobilis Flower Extract

No known risks

A Roman chamomile flower extract or oil used for skin conditioning and fragrance. Cosmetic safety reviewers concluded that Anthemis nobilis-derived ingredients are safe in current practices when formulated to be non-sensitising. People allergic to plants in the daisy family may be more likely to react.

Sources: CIR: Safety Assessment of Anthemis nobilis-Derived Ingredients as Used in Cosmetics https://cir-safety.org/sites/default/files/anthem122013final.pdf

Hydrolyzed Algin

No known risks

An algae- or seaweed-derived ingredient used for skin conditioning, moisturising or texture support. Composition and trace mineral content vary by source. No pregnancy-specific hazard was identified for normal topical cosmetic exposure; this does not assess oral seaweed supplements.

Sources: CIR: Safety Assessment of Brown Algae-Derived Ingredients as Used in Cosmetics; European Commission CosIng ingredient inventory; relevant algal cosmetic-ingredient literature.

Pantethine

No known risks

pantethine is a vitamin B5-related conditioning ingredient. Relevant cosmetic-family evidence supports topical use, and no reproductive or developmental hazard signal was identified for ordinary cosmetic exposure. No pregnancy-specific concern was identified for normal topical use.

Sources: CIR safety assessment of panthenol and pantothenic-acid derivatives; European Commission CosIng ingredient inventory.

Caffeine

No known risks

Methylxanthine used in cosmetics (e.g., de-puffing/firming and antioxidant support). No pregnancy-specific contraindications are identified for topical cosmetic use.

Sources: CIR (Methylxanthines); PubMed (NLM)

Lecithin

No known risks

Emulsifier and skin-conditioning ingredient composed of phospholipids. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

Sodium Rna

No known risks

Ordinary unmodified Sodium RNA is a large charged conditioning biopolymer with no meaningful systemic delivery pathway during normal skin use and no known pregnancy-specific risk.

Sources: https://patentimages.storage.googleapis.com/57/f1/03/3241e6e95c6048/US20090220481A1.pdf, https://inci.personalcarecouncil.org/inci-conventions-test.pdf

Bisabolol

No known risks

A terpene alcohol used for skin conditioning and soothing. Cosmetic safety reviewers reaffirmed bisabolol as safe at current cosmetic concentrations, and reproductive and developmental testing did not identify adverse effects. Bisabolol can increase skin penetration, so formulators should consider the safety of other ingredients in the same product.

Sources: CIR: Final Report on the Safety Assessment of Bisabolol https://cir-reports.cir-safety.org/view-attachment/?id=6fcf160b-8e74-ec11-8943-0022482f06a6; CIR re-review material https://www.cir-safety.org/sites/default/files/bisabolol.pdf

Squalane

No known risks

Lightweight emollient used to support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Glycerin

No known risks

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Oleth-3 Phosphate

No known risks

A long-chain phosphate emulsifier. Structure-specific read-across supports ordinary nonirritating topical formulations without an identified pregnancy concern. Contact allergy has been reported in an individual using hair wax.

Sources: https://www.crodabeauty.com/en-gb/products/product/106-crodafos_1_o3a, https://journals.sagepub.com/doi/pdf/10.1177/1091581812444141, https://cir-safety.org/sites/default/files/alkpht092014FR.pdf, https://pubmed.ncbi.nlm.nih.gov/9385523/

Caprylyl Glycol

No known risks

Humectant and preservative booster used to support product stability. Low systemic exposure expected from topical cosmetic use.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Oleth-3

No known risks

Oleth-3: An alkyl PEG ether assessed for cosmetic use in non-irritating formulations. Manufacture should control ethylene oxide and 1,4-dioxane residues. This is not a sulfated surfactant; findings for laureth sulfates should not be transferred to this distinct identity. No pregnancy-specific harm has been identified for ordinary topical cosmetic use; direct human pregnancy data are limited.

Sources: https://pubmed.ncbi.nlm.nih.gov/23064774/,https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Oleth-5

No known risks

Oleth-5: An alkyl PEG ether assessed for cosmetic use in non-irritating formulations. Manufacture should control ethylene oxide and 1,4-dioxane residues. This is not a sulfated surfactant; findings for laureth sulfates should not be transferred to this distinct identity. No pregnancy-specific harm has been identified for ordinary topical cosmetic use; direct human pregnancy data are limited.

Sources: https://pubmed.ncbi.nlm.nih.gov/23064774/,https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Choleth-24

No known risks

Choleth-24 is an ethoxylated cholesterol-derived emulsifier. CIR lists this exact ingredient as safe in current cosmetic use; no pregnancy-specific hazard was identified for ordinary topical exposure. Direct human pregnancy studies of this exact ingredient were not identified; the rating applies to normal topical cosmetic use.

Sources: https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Hydrogenated Lecithin

No known risks

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

Jojoba Wax PEG-120 Esters

No known risks

Hallstar's own formula names Jojoba Wax PEG-120 Esters as Florasolvs Jojoba-120. Explicit structural read-across, not direct named membership: long-chain jojoba acids/alcohols bearing a large PEG chain; PEGylated lipid reports cover the PEG and fatty-lipid domains. Residual ethylene oxide/1,4-dioxane require purification; the high polymeric hydrophilic mass limits systemic delivery. Nonirritating formulation, not ingredient-name absence of data, supports the conclusion. Ordinary purified cosmetic emulsifier/solubiliser in finished leave-on and rinse-off products; not raw chemical on injured skin. Pregnancy-specific human evidence is limited. This is an ordinary topical assessment, not unrestricted oral, neat-oil or therapeutic clearance.

Sources: https://www.cir-safety.org/sites/default/files/pegoil122012final_faa-final%20for%20posting.pdf, https://www.hallstarbeauty.com/webfoo/wp-content/uploads/TheWaterlessWave_HallstarBeauty.pdf

Ceteth-24

No known risks

Ceteth-24: An alkyl PEG ether assessed for cosmetic use in non-irritating formulations. Manufacture should control ethylene oxide and 1,4-dioxane residues. This is not a sulfated surfactant; findings for laureth sulfates should not be transferred to this distinct identity. No pregnancy-specific harm has been identified for ordinary topical cosmetic use; direct human pregnancy data are limited.

Sources: https://pubmed.ncbi.nlm.nih.gov/23064774/,https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Tocopheryl Acetate

No known risks

Tocopheryl acetate (vitamin E derivative) is used as an antioxidant and skin-conditioning ingredient; it is considered low concern in topical use with no known pregnancy or breastfeeding risks at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Carbomer

No known risks

Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Tetrasodium EDTA

No known risks

Chelating agent used to stabilise formulations; minimal dermal absorption and no known pregnancy or breastfeeding risks at typical cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Xanthan Gum

No known risks

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

Potassium Sorbate

No known risks

Preservative widely used in foods and cosmetics. Considered safe at regulated concentrations with low systemic exposure from topical use.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

Disodium EDTA

No known risks

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

CI 14700

No known risks

A Colour Index or lake name for a regulated cosmetic colour additive. Permitted product areas differ by colour, and certified colours must meet applicable identity and purity specifications. No pregnancy-specific concern was identified for compliant topical cosmetic use.

Sources: FDA: Regulatory Status of Color Additives https://hfpappexternal.fda.gov/scripts/fdcc/index.cfm?set=ColorAdditives; FDA: Color Additives Permitted for Use in Cosmetics https://www.fda.gov/cosmetics/cosmetic-ingredient-names/color-additives-permitted-use-cosmetics; 21 CFR Parts 73, 74 and 82.

CI 19140

No known risks

Also known as FD&C Yellow No. 5 or tartrazine, this certified colour additive is used in cosmetics and other regulated products. FDA permits its use in cosmetics, including the eye area, when identity, purity, certification and use requirements are met. Rare allergy-like reactions can occur, but no pregnancy-specific concern is identified for normal use in a compliant finished cosmetic.

Sources: FDA: Regulatory Status of FD&C Yellow No. 5 / C.I. 19140 https://www.hfpappexternal.fda.gov/scripts/fdcc/index.cfm?id=FDCYellow5&set=ColorAdditives; FDA: Color Additives and Cosmetics Fact Sheet https://www.fda.gov/industry/color-additives/color-additives-and-cosmetics-fact-sheet

Full recorded ingredient list

Water, Bifida Ferment Lysate, PEG-8, Propanediol, Bis-PEG-18 Methyl Ether Dimethyl Silane, Methyl Gluceth-20, Glycereth-26, PEG-75, Butylene Glycol, Adansonia Digitata Seed Extract, Tripeptide-32, Sodium Hyaluronate, Yeast Extract, Lactobacillus Ferment, Cola Acuminata Seed Extract, Anthemis Nobilis Flower Extract, Hydrolyzed Algin, Pantethine, Caffeine, Lecithin, Sodium Rna, Bisabolol, Squalane, Glycerin, Oleth-3 Phosphate, Caprylyl Glycol, Oleth-3, Oleth-5, Choleth-24, Hydrogenated Lecithin, Jojoba Wax PEG-120 Esters, Ceteth-24, Tocopheryl Acetate, Carbomer, Triethanolamine, Tetrasodium EDTA, BHT, Xanthan Gum, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, CI 14700, CI 19140

Ingredient ratings refreshed 15 October 2026. Formulas vary by market and can change. Always compare with your packaging.

Questions about this assessment

Why does Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum have a Medium risk rating?

The recorded formula includes 3 ingredient entries with risk flags: BHT (Medium risk), Triethanolamine (Low risk), Phenoxyethanol (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail. The product score is a stored assessment, not a clinical safety guarantee.

Has every ingredient in Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum been assessed?

43 of 43 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.

Does this assessment apply to my Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum?

Only if the ingredient list on your packaging matches the recorded formula shown here. Formulas can differ by market and change over time. Compare the full list, not just the product name; report a mismatch if it differs.

Does this pregnancy assessment also establish breastfeeding suitability?

No. This page presents a pregnancy-focused product assessment. Do not infer a breastfeeding conclusion from its score or label; breastfeeding requires a separate assessment of the formula and how it is used.