DayWear Anti-Oxidant 24-Hour Moisturizer Cream SPF 15 for Normal/Combination Skin

Dimethicone is a silicone polymer used as a skin protectant and slip/conditioning agent. It is considered inert with minimal dermal absorption; the main practical issues are cosmetic (feel) and occasional irritation in very sensitive users. It is not a pregnancy-specific concern in topical cosmetic use.

Sources: CIR: Amended Safety Assessment of Dimethicone, Methicone, and Substituted-Methicone Polymers as Used in Cosmetics https://cir-safety.org/supplementaldoc/amended-safety-assessment-dimethicone-methicone-and-substituted-methicone-polymers-2

A crosslinked silicone elastomer used as a film former and texture ingredient. Cosmetic safety reviewers concluded that Polysilicone-11 is safe in current cosmetic use. MamaSkin classifies it as low risk for consistency with the existing silicone-polymer policy and because cosmetic-grade manufacturing should control residual starting materials, rather than because of a known pregnancy-specific contraindication.

Sources: CIR: Safety Assessment of Polysilicone-11 as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-polysilicone-11-used-cosmetics

Polygonum cuspidatum root extract, also called Japanese knotweed root extract, is a botanical source of resveratrol, polydatin and related polyphenols. Extract composition and cosmetic concentration vary, and normal topical exposure is expected to be much lower than high-dose oral supplementation. MamaSkin applies a precautionary Low Risk classification for consistency with its existing topical resveratrol policy, not because cosmetic use is a known pregnancy contraindication.

Sources: PubMed: Polygonum cuspidatum root contains resveratrol, polydatin and emodin https://pubmed.ncbi.nlm.nih.gov/23075087/; PubMed: Polygonum cuspidatum as a concentrated resveratrol source https://pubmed.ncbi.nlm.nih.gov/29403824/; PubMed: cautionary pregnancy findings from high-dose oral resveratrol in nonhuman primates https://pubmed.ncbi.nlm.nih.gov/24563374/; PubMed: topical resveratrol delivery and skin disposition https://pubmed.ncbi.nlm.nih.gov/28389713/; existing MamaSkin resveratrol policy.

A high-molecular-weight silicone polyether used for emulsification, texture and conditioning. Cosmetic safety reviewers concluded that this ingredient is safe in current cosmetic use, and absorption of the intact polymer is expected to be limited. MamaSkin classifies it as low risk for consistency with its established dimethicone-family policy and because cosmetic-grade manufacturing should control residual starting materials, not because of a known pregnancy-specific contraindication.

Sources: CIR: Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone conclusion in the December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Glycyrrhetinic Acid is a biologically active licorice-derived constituent used for soothing and skin conditioning. High oral licorice exposure is discouraged during pregnancy, but this does not establish equivalent risk from normal topical cosmetic exposure. MamaSkin applies a precautionary Low Risk classification for consistency with its existing licorice-root and glycyrrhizate policy.

Sources: CIR: Safety Assessment of Glycyrrhetinic Acid and Glycyrrhetinate ingredients https://cir-reports.cir-safety.org/view-attachment/?id=49a63435-8e74-ec11-8943-0022482f06a6; NIH ODS: Dietary Supplements and Life Stages - Pregnancy https://ods.od.nih.gov/factsheets/Pregnancy-HealthProfessional/; existing MamaSkin licorice-family policy.

Nordihydroguaiaretic acid is a biologically active antioxidant. Systemic animal studies found chronic toxicity and effects on male reproductive tissues, but normal topical cosmetic exposure and pregnancy outcomes have not been adequately studied. MamaSkin therefore treats it as Low Risk rather than assuming either safety or a proven fetal hazard.

Sources: Chronic oral mouse study https://pubmed.ncbi.nlm.nih.gov/25380600/; rat spermatogenesis and fertility study https://pubmed.ncbi.nlm.nih.gov/29110321/

Butyloctyl salicylate is a salicylate ester that the CIR panel considered safe as used in cosmetics when formulated to be non-irritating. Available safety data support low dermal toxicity, and at typical cosmetic use levels the expected systemic salicylate exposure from topical application is far below oral salicylate exposure, which fits a low-risk classification.

Sources: MotherToBaby: Topical acne treatments including salicylic acid https://www.ncbi.nlm.nih.gov/books/NBK582985/

No matched ingredient rating is available yet. Not assessed does not mean safe or unsafe.

No matched ingredient rating is available yet. Not assessed does not mean safe or unsafe.

No matched ingredient rating is available yet. Not assessed does not mean safe or unsafe.

No matched ingredient rating is available yet. Not assessed does not mean safe or unsafe.

Purified water, distilled water and Aqua are names or grades of water used as a cosmetic solvent. No pregnancy-specific risk is identified from ordinary topical use. This identity does not include rose water, herbal distillates or other botanical waters, which have their own constituents and assessments.

Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

polyester-8 is a cosmetic polymer, film former or high-molecular-weight texture aid. Systemic dermal absorption is expected to be limited when manufactured with appropriate residual-monomer and impurity controls. No pregnancy-specific concern was identified for normal cosmetic use; avoid inhaling airborne powder or spray droplets.

Sources: CIR polymer safety assessments and Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng ingredient inventory

cetyl ricinoleate is a cosmetic emollient, ester or lipid-derived formulation aid. Relevant family evidence supports normal cosmetic use with irritation, sensitisation and purity qualifications retained where applicable. No pregnancy-specific concern was identified for ordinary topical exposure.

Sources: CIR assessments of cosmetic esters, fatty acids and fatty acid salts https://www.cir-safety.org/supplementaldoc/safety-assessment-fatty-acids-fatty-acid-salts-used-cosmetics; European Commission CosIng

An ethoxylated fatty alcohol used mainly as an emulsifier, surfactant or solubiliser. Cosmetic safety reviewers concluded that alkyl PEG/PPG ethers are safe in current practices when formulated to be non-irritating. Manufacturing controls should limit residual ethylene oxide and 1,4-dioxane.

Sources: CIR: Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-alkyl-peg/ppg-ethers-used-cosmetics

An ethoxylated fatty alcohol used mainly as an emulsifier, surfactant or solubiliser. Cosmetic safety reviewers concluded that alkyl PEG/PPG ethers are safe in current practices when formulated to be non-irritating. Manufacturing controls should limit residual ethylene oxide and 1,4-dioxane.

Sources: CIR: Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-alkyl-peg/ppg-ethers-used-cosmetics

A long-chain emollient ester. Exact-ingredient skin testing and constituent toxicology support ordinary cosmetic use up to 5% without an identified pregnancy concern. It should not be confused with short-chain fumarate medicines.

Sources: https://cir-reports.cir-safety.org/view-attachment?id=25d2a583-8c74-ec11-8943-0022482f06a6, https://hpvchemicals.oecd.org/UI/handler.axd?id=9802ef92-2c9d-4f21-877e-90b6133efd73, https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

A fatty ester, triglyceride or lipid emollient. These materials have low expected systemic exposure and no pregnancy-specific hazard was identified for normal topical use.

Sources: CIR assessments of fatty esters, triglycerides and emollients; European Commission CosIng.

A botanical extract or plant water used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng; CIR botanical safety framework and relevant plant-family assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

gentiana lutea root extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not an essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf; European Commission CosIng

Fatty alcohol used as an emollient and stabiliser. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

An algae- or seaweed-derived ingredient used for skin conditioning, moisturising or texture support. Composition and trace mineral content vary by source. No pregnancy-specific hazard was identified for normal topical cosmetic exposure; this does not assess oral seaweed supplements.

Sources: CIR: Safety Assessment of Brown Algae-Derived Ingredients as Used in Cosmetics; European Commission CosIng ingredient inventory; relevant algal cosmetic-ingredient literature.

A rosemary leaf extract used mainly for skin conditioning and antioxidant support. Cosmetic safety reviewers concluded that rosemary leaf extract is safe at the reviewed cosmetic use levels when formulated to be non-sensitising. It is distinct from concentrated rosemary essential oil, and botanical allergy remains possible.

Sources: CIR: Safety Assessment of Rosmarinus officinalis (Rosemary)-Derived Ingredients as Used in Cosmetics https://www.cir-safety.org/sites/default/files/rosmarinus_2.pdf

Triticum Vulgare (Wheat) Germ Extract: This exact wheat germ/bran preparation is included among the supported ingredients in the published wheat-derived cosmetic assessment. That conclusion does not cover wheat sprout extract. Manufacturing impurities and residual allergenic proteins remain relevant; avoid if allergic to wheat. No pregnancy-specific harm has been identified for ordinary topical cosmetic use; direct human pregnancy data are limited.

Sources: https://journals.sagepub.com/doi/10.1177/10915818241294063,https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

artemia extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

Methylxanthine used in cosmetics (e.g., de-puffing/firming and antioxidant support). No pregnancy-specific contraindications are identified for topical cosmetic use.

Sources: CIR (Methylxanthines); PubMed (NLM)

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

citrus medica limonum fruit extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

hydrolyzed rice extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

Vitis Vinifera (Grape) Seed Extract: This exact botanical extract is included in the relevant cosmetic-use assessment. Plant species, part and preparation are preserved. Botanical composition, impurities and source allergy remain relevant; non-irritating and non-sensitizing formulation is required where specified by the assessment. Oral supplements and medicinal doses are outside this rating. No pregnancy-specific harm has been identified for ordinary topical cosmetic use; direct human pregnancy data are limited.

Sources: https://www.cir-safety.org/supplementaldoc/safety-assessment-vitis-vinifera-grape-derived-ingredients-used-cosmetics,https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Hydrolyzed Rice Bran Extract: An assessed hydrolyzed rice-bran preparation. Cosmetic purity and source allergy matter; hydrolysis and plant part remain distinct from rice oil or a concentrated medicinal extract. No pregnancy-specific harm has been identified for ordinary topical cosmetic use; direct human pregnancy data are limited. This assessment excludes ingestion, medicinal doses and deliberate inhalation.

Sources: https://journals.sagepub.com/doi/10.1080/10915810600964626,https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

thermus thermophillus ferment is a fermentation-, microbial- or algae-derived cosmetic conditioning material. The assessment applies to the defined cosmetic ingredient rather than live organisms or oral supplements. No pregnancy-specific concern was identified for normal topical use; formulation purity and sensitivity remain relevant.

Sources: CIR assessments of microbial polysaccharides, fermentation-derived and algae-derived cosmetic ingredients; CIR Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Long-chain fatty alcohol used as an emollient and thickener. This is not the same concern profile as simple drying alcohols; reviewed cosmetic safety sources support normal topical use.

Sources: CIR: Final Report on the Safety Assessment of Cetearyl Alcohol, Cetyl Alcohol, Isostearyl Alcohol, Myristyl Alcohol, and Behenyl Alcohol; EU CosIng / cosmetics regulatory inventory

Acrylic Acid/VP Crosspolymer: An assessed vinylpyrrolidone polymer. Control residual monomers and solvents; the finished polymer is distinct from free reactive monomers and uncured nail materials. No pregnancy-specific harm has been identified for ordinary topical cosmetic use; direct human pregnancy data are limited. This assessment excludes ingestion, medicinal doses and deliberate inhalation.

Sources: https://journals.sagepub.com/doi/10.1177/10915818241267203,https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

A long-chain modified vinylpyrrolidone polymer used as a film former and texture aid. CIR included Triacontanyl PVP in its safe-as-used conclusion for vinylpyrrolidone polymers. The large polymer is not equivalent to free N-vinyl-2-pyrrolidone monomer, and no pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Vinylpyrrolidone Polymers as Used in Cosmetics https://www.cir-safety.org/sites/default/files/vinylp122018final.pdf

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Alkyl benzoate emollient used in cosmetics; available cosmetic safety assessments do not indicate pregnancy-specific concerns with routine topical use.

Sources: CIR Safety Assessment of Alkyl Benzoates (2012); CIR alkyl benzoates dossier / C12-15 alkyl benzoate data.

This naturally occurring fatty acid is used for emolliency, cleansing support or texture. The Cosmetic Ingredient Review concluded that assessed fatty acids are safe in current cosmetic use when formulated to be non-irritating and non-sensitizing; some can increase penetration of other formula ingredients.

Sources: CIR: Safety Assessment of Fatty Acids and Fatty Acid Salts as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-fatty-acids-fatty-acid-salts-used-cosmetic

Skin-conditioning lipid used in barrier-support formulas, often alongside ceramides and fatty acids. Normal topical cosmetic use has no known pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

Sources: CIR cosmetic ingredient safety references for cholesterol and related sterols; EU CosIng / cosmetics regulatory inventory

Lightweight emollient used to support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Natural-moisturising-factor humectant that helps bind water in the stratum corneum. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of PCA and Its Salts as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

A naturally occurring component of skin moisturizing factors, used in cosmetics as a humectant and at higher concentrations as a keratolytic. Ordinary cosmetic use does not identify a pregnancy-specific concern. Higher-strength products may sting or irritate damaged skin. Urea itself is distinct from formaldehyde-releasing preservatives such as imidazolidinyl urea and diazolidinyl urea.

Sources: CIR ingredient record: Urea https://cir-safety.org/ingredient/urea; EU CosIng cosmetic ingredient inventory: Urea

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

dipropylene glycol dibenzoate is a cosmetic formulation, mineral, sugar-derived or organic-acid ingredient. Available identity, use and related safety evidence did not identify a pregnancy-specific concern for normal topical cosmetic exposure. Cosmetic-grade purity and ordinary irritation precautions remain applicable.

Sources: CIR ingredient and related-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

Tocopheryl acetate (vitamin E derivative) is used as an antioxidant and skin-conditioning ingredient; it is considered low concern in topical use with no known pregnancy or breastfeeding risks at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

A high-molecular-weight polymer used to thicken and stabilise formulas. Cosmetic safety reviewers concluded that acryloyldimethyltaurate polymers are safe in current practices. Residual monomers should be controlled during manufacture.

Sources: CIR: Acryloyldimethyltaurate Polymers final assessment, April 2017; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

A lipid-soluble ester of vitamin C used as an antioxidant and skin-conditioning ingredient. The Cosmetic Ingredient Review concluded that tetrahexyldecyl ascorbate is safe in current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified for normal topical exposure.

Sources: CIR: Safety Assessment of Ethers and Esters of Ascorbic Acid https://www.cir-safety.org/supplementaldoc/safety-assessment-ethers-and-esters-ascorbic-acid-used-cosmetics-0

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

A naturally occurring small molecule used for antioxidant, conditioning or cellular-energy support in cosmetics. Creatine and ergothioneine occur in human or dietary biology, and no pregnancy-specific hazard signal was identified for the much smaller exposure expected from normal topical cosmetic use. This classification does not assess concentrated oral supplements.

Sources: European Commission CosIng ingredient inventory; PubMed literature on topical Creatine and Ergothioneine, dermal delivery and cosmetic use; ECHA substance information where available.

Low-viscosity isoparaffin emollient used for slip and lightweight texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Isoparaffins as Used in Cosmetics / CIR Quick Reference Table (Isohexadecane); EU CosIng / cosmetics regulatory inventory

A benzoate ester of a large propoxylated stearyl ether. Explicit parent-polyether and benzoate-metabolite evidence supports no identified pregnancy concern in ordinary nonirritating topical use. Direct pregnancy studies of this exact ester are limited; drug-delivery or raw-material exposure is outside scope.

Sources: https://kcia.or.kr/cid/search/ingd_view.php?no=4509, https://www.cir-safety.org/sites/default/files/RR_PPG%20Stearyl%20Ethers.pdf, https://journals.sagepub.com/doi/10.1177/10915818231204265, https://www.canada.ca/en/environment-climate-change/services/evaluating-existing-substances/final-screening-assessment-benzoates.html

Sugar-derived humectant used to help bind water and improve skin feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR: Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A large phosphorylcholine-containing conditioning polymer. Cosmetic safety reviewers concluded that acryloyloxyethyl phosphorylcholine polymers, including polyquaternium-51, are safe in current practices. Available testing did not indicate sensitisation, and dermal absorption of the finished polymer is expected to be limited.

Sources: CIR: Safety Assessment of Acryloyloxyethyl Phosphorylcholine Polymers as Used in Cosmetics https://www.cir-safety.org/sites/default/files/FR_AcryloyloxyethylPhosphorylcholinePolymers_062022.pdf

Nonionic emulsifier and solubilizer used to disperse oils in cosmetic formulas. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.

Sources: CIR: Safety Assessment of Polysorbates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Emulsifier and skin-conditioning ingredient composed of phospholipids. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

fumaric acid is a cosmetic formulation, mineral, sugar-derived or organic-acid ingredient. Available identity, use and related safety evidence did not identify a pregnancy-specific concern for normal topical cosmetic exposure. Cosmetic-grade purity and ordinary irritation precautions remain applicable.

Sources: CIR organic-acid and related salt safety assessments; European Commission CosIng; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025

A fatty-modified, charged starch polymer used for skin conditioning. Its defined network chemistry supports ordinary non-irritating topical use, with no pregnancy-specific concern identified.

Sources: https://kcia.or.kr/cid/search/ingd_view.php?no=13694, https://www.cir-safety.org/sites/default/files/plpogu092015final.pdf, https://journals.sagepub.com/doi/10.1177/1091581812467378

Humectant and preservative booster used to support product stability. Low systemic exposure expected from topical cosmetic use.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

A plant-derived carbohydrate polymer or modified starch used to thicken, stabilise or condition a formula. Cosmetic safety reviewers concluded that the supported plant polysaccharide gums and derivatives are safe in current practices of use and concentration. Loose powders should still be used without deliberately inhaling airborne particles.

Sources: CIR: Safety Assessment of Plant Polysaccharide Gums as Used in Cosmetics https://www.cir-safety.org/panelbook/safety-assessment-plant-polysaccharide-gums-used-cosmetics

pH adjuster used in very small quantities to balance formulations. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

Sodium chloride is used to adjust viscosity and texture in formulations; topical cosmetic use is considered low concern with no known pregnancy or breastfeeding risks.

Sources: CIR; EU/UK Cosmetics Regulation

Ascorbyl Tocopheryl Maleate: An assessed vitamin-E-related cosmetic antioxidant. Ordinary topical exposure differs from high-dose supplements; manufacturing quality and oxidation control remain important. This is not a retinoate. No pregnancy-specific harm has been identified for ordinary topical cosmetic use; direct human pregnancy data are limited. This assessment excludes ingestion, medicinal doses and deliberate inhalation.

Sources: https://www.cir-safety.org/sites/default/files/tocoph032014FR.pdf,https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

Antioxidant and stabilizer used to protect cosmetic formulas from oxidation. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR cosmetic ingredient safety references for hindered phenolic antioxidants; EU CosIng / cosmetics regulatory inventory

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

A preservative used at low concentrations to keep cosmetic formulas microbiologically stable. Cosmetic safety reviewers concluded that sodium dehydroacetate is safe in current cosmetic use and reaffirmed that conclusion in 2023 after reviewing updated exposure and safety information. Rare contact hypersensitivity has been reported, but no pregnancy-specific concern is identified for normal topical cosmetic exposure.

Sources: CIR: 2023 Re-Review Summary for Sodium Dehydroacetate and Dehydroacetic Acid https://www.cir-safety.org/sites/default/files/RRsum_SodiumDehydroacetate_122023.pdf

Exact formatting/common-name variant of ci 42090; it inherits the canonical scientific assessment. Also known as FD&C Blue No. 1 or Brilliant Blue FCF, this certified colour additive is used to colour cosmetic formulas. FDA permits it in cosmetics, including the eye area, when identity, purity, certification and use requirements are met. No pregnancy-specific concern is identified for normal use in a compliant finished cosmetic.

Sources: FDA: Regulatory Status and identity information for FD&C Blue No. 1 / C.I. 42090 https://www.hfpappexternal.fda.gov/scripts/fdcc/index.cfm?id=FDCBLUENO1&set=FoodSubstances; FDA: Color Additives Permitted for Use in Cosmetics https://www.fda.gov/cosmetics/cosmetic-ingredient-names/color-additives-permitted-use-cosmetics

A Colour Index or lake name for a regulated cosmetic colour additive. Permitted product areas differ by colour, and certified colours must meet applicable identity, purity, batch-certification and use requirements. No pregnancy-specific concern was identified for compliant topical cosmetic use.

Sources: FDA: Regulatory Status of Color Additives https://hfpappexternal.fda.gov/scripts/fdcc/index.cfm?set=ColorAdditives; FDA: Color Additives Permitted for Use in Cosmetics https://www.fda.gov/cosmetics/cosmetic-ingredient-names/color-additives-permitted-use-cosmetics; 21 CFR Parts 73, 74 and 82.